KMID : 0368820040430050524
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Journal of the Korean Neuropsychiatr Association 2004 Volume.43 No. 5 p.524 ~ p.528
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Monocyte Chemoattractant Protein-1(MCP1) -2518 Polymorphism and Bipolar I Disorder
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Abstract
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Objectives: Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD.
Methods: Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method.
Results: Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups.
Conclusion: Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.
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KEYWORD
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